US Signs Health Agreements with Uganda and Lesotho

On 10 December 2025, in Kampala, the United States of America (USA) and Uganda signed a bilateral health cooperation agreement worth nearly USD 2.3 billion spanning five years. In line with its Global Health Strategy (#GHS), the US plans to invest up to USD 1.7 billion, while Uganda will co-invest USD 500 million for enhancing the health system in Uganda.

It represents a new approach of the US in the fight against prevalent diseases in Africa, such as HIV/AIDS, TB, and Pf. From the Ugandan perspective, the Agreement is aligned with #Vision2040Uganda and its National Development Plan (#NDP) IV, which lays emphasis on digitalization to improve health services. The Agreement also provides support for faith-based medical care providers and health care services to the Ugandan military.

Similarly, the US and Lesotho signed a five-year bilateral health agreement worth USD 364 million. Based on the Agreement, the US will provide USD 232 million, while Lesotho will come up with USD 132 million. In Lesotho, one of the main health issues is HIV/AID. In addition, the funds will go toward improving internet connectivity for health facilities and the application of robotics for the delivery of life-saving medical products.

These two Agreements come in the wake of the landmark one signed between the US and Kenya. The US is in negotiations with several countries to sign similar health cooperation agreements. These deals are based on the new #AmericaFirst Global Health Strategy, which came into being after the dismantling of #USAID.